DSIP

DSIP (Delta Sleep-Inducing Peptide) is an endogenous, naturally occurring nonapeptide (9 amino acids) first isolated from the brain and cerebrospinal fluid of mammals. It is a central regulatory neuropeptide that modulates sleep architecture, stress response, circadian rhythm, and neuroendocrine function.

2mg*10vials

$40

5mg*10vials

$50

Product Information

What is DSIP?

DSIP (Delta Sleep-Inducing Peptide) is an endogenous, naturally occurring nonapeptide (9 amino acids) first isolated from the brain and cerebrospinal fluid of mammals. It is a central regulatory neuropeptide that modulates sleep architecture, stress response, circadian rhythm, and neuroendocrine function.

Core Physicochemical Properties

Full Name: Delta Sleep-Inducing Peptide
Sequence: Trp‑Ala‑Gly‑Gly‑Asp‑Ala‑Ser‑Gly‑Glu
CAS Number: 62568‑57‑4
Molecular Formula: C₃₅H₄₉N₉O₁₅
Molecular Weight: ~823.8 Da
Endogenous Location: Hypothalamus, limbic system, pineal gland
Half-life: Very short in circulation (~3–9 minutes), but produces long‑lasting regulatory effects via gene expression and receptor modulation
Pharmacological Category: Central neuromodulator, sleep regulator, adaptogen, neuroprotective peptide

Biological Identity

DSIP is not a sedative or hypnotic drug. It is a physiological sleep regulator that promotes natural, restful sleep by increasing delta wave (slow‑wave sleep) activity. It also acts as an endogenous stress‑protective peptide that normalizes disrupted neuroendocrine and circadian systems.

Target Population & Clinical/Research Applications

Primary Target Groups

Individuals with sleep disorders
- Insomnia (difficulty falling asleep, frequent nighttime awakenings)
- Non‑restorative sleep, poor sleep quality
- Circadian rhythm disruption (jet lag, shift work sleep disorder)
Chronic stress and anxiety sufferers
- High psychological stress, burnout, fatigue
- Anxiety‑related sleep disturbance
- Stress‑induced hormonal imbalance (elevated cortisol)
Neuroendocrine dysregulation
- Abnormal cortisol rhythm (morning fatigue, evening hyperarousal)
- Mild hypothalamic‑pituitary‑adrenal (HPA) axis dysfunction
- Post‑traumatic or post‑surgical stress response
Cognitive fatigue and brain fog
- Mental exhaustion, poor concentration, memory lapses
- Chronic fatigue syndrome (CFS)
- Age‑related cognitive slowdown
Recovery support
- Post‑exercise overtraining syndrome
- Post‑illness / post‑COVID fatigue
- Post‑surgical recovery

Mechanism of Action (Molecular & Neurophysiological)

DSIP acts as a central neuromodulator with multiple coordinated pathways:

1. Sleep Regulation (Core Mechanism)

Enhances delta‑wave activity (slow‑wave, deep sleep) in the brain
Promotes natural sleep architecture without artificial sedation
Increases the duration and quality of restorative sleep
Does not induce hypnosis or chemical sedation

2. HPA Axis Modulation & Stress Control

Normalizes cortisol secretion rhythm
Reduces excessive stress‑induced cortisol elevation
Restores balance between catabolic (stress) and anabolic (recovery) processes
Acts as an endogenous adaptogen against chronic stress

3. Neurotransmitter Balance

Modulates GABA, serotonin, norepinephrine, and dopamine systems
Reduces central nervous system hyperarousal
Stabilizes excitatory/inhibitory neurotransmission
Supports calmness without drowsiness

4. Neuroprotective & Anti‑Oxidative Effects

Reduces lipid peroxidation and free radical damage
Protects neurons from excitotoxicity and hypoxic injury
Supports mitochondrial function and cellular recovery
May upregulate endogenous antioxidant systems

5. Neuroendocrine Regulation

Modulates release of growth hormone, melatonin, and luteinizing hormone
Supports anabolic recovery processes
Helps restore disrupted circadian endocrine rhythms