5-Amino-1MQ

5-Amino-1MQ (synonyms: NNMTi; 5-Amino-1-methylquinolin-1-ium) is a potent, membrane-permeable small-molecule inhibitor of nicotinamide N-methyltransferase (NNMT). It is not a peptide but a synthetic quinolinium derivative with a well-characterized mechanism of enzyme inhibition.

5mg*10vials

$45

10mg*10vials

$70

Product Information

Target User Populations (Research-Supported & Preclinical Indications)

5-Amino-1MQ is investigational and not approved for clinical use by the FDA, EMA, or other regulators. It is used in preclinical research and by those focused on metabolic health and longevity.

Adults with Metabolic Dysregulation

Overweight/obesity, visceral fat, and abnormal lipid metabolism
Prediabetes, insulin resistance, and elevated HOMA-IR
Metabolic syndrome with central obesity and chronic low-grade inflammation

Aging Populations with Mitochondrial Decline

Adults 45+ with age-related mitochondrial dysfunction, low endurance, and muscle weakness
Longevity enthusiasts supporting NAD⁺, sirtuin activity, and cellular anti-aging resilience

Individuals with Reduced Energy Expenditure

Sedentary people with low basal metabolic rate and fat-storing tendencies
Athletes and bodybuilders seeking improved fat oxidation, lean mass retention, and performance

Research-Specific Groups

Researchers studying NNMT inhibition in obesity, diabetes, neurodegeneration, and aging
Those testing combinations with metabolic peptides (e.g., AOD‑9604, semaglutide) for body recomposition

Benefits for Healthy Adults (Preclinical & Research-Supported)

1. Metabolic Improvement & Body Composition

Fat Loss Without Calorie Restriction: Reduces adiposity and visceral fat mass in DIO mice, independent of food intake.
Insulin Sensitivity Enhancement: Lowers HOMA-IR and improves glucose tolerance, supporting metabolic health.
Lean Muscle Preservation: Maintains muscle mass during weight loss, supporting muscle regeneration and exercise performance.

2. Cellular Longevity & NAD⁺ Homeostasis

NAD⁺ Boosting: Restores age-related NAD⁺ decline, activating sirtuins and PARPs to support DNA repair and cellular resilience.
Mitochondrial Health: Enhances mitochondrial biogenesis and function, reducing oxidative stress and age-related metabolic decline.

3. Energy & Exercise Performance

Increased Energy Expenditure: Raises basal metabolic rate (BMR) via improved mitochondrial function, supporting fat oxidation.
Endurance & Strength: Improves exercise endurance and muscle strength in preclinical models, beneficial for active individuals.

4. Anti-Inflammatory & Neuroprotective Effects

Reduced Chronic Inflammation: Lowers pro-inflammatory markers via SIRT1-mediated pathways, supporting systemic metabolic health.
Cognitive/Neuronal Support: Neuroprotective effects in Parkinson’s models, with potential implications for age-related cognitive decline.