Selank

Selank (CAS: 129954-34-3) is a synthetic heptapeptide (7 amino acids) developed by the Institute of Molecular Genetics, Russian Academy of Sciences. It is a stabilized analog of the endogenous immunomodulatory peptide tuftsin (Thr-Lys-Pro-Arg), engineered for antianxiety, nootropic, neuroprotective, and immunomodulatory effects. It is approved in Russia for generalized anxiety disorder (GAD) and neurasthenia (nervous exhaustion).

5mg*10vials

$50

10mg*10vials

$75

Product Information

Target Population & Applications

Approved Uses

Generalized Anxiety Disorder (GAD)
Neurasthenia (nervous exhaustion, asthenia)
Anxiety with depression, apathy, emotional lability
Stress-related cognitive impairment

Research & Off-Label Uses

Social anxiety, performance anxiety, phobias
PTSD, adjustment disorders, chronic stress
Mild cognitive impairment, memory decline
ADHD (adjunctive: focus, emotional regulation)
Chronic fatigue syndrome (CFS)
Neuroinflammation, neurodegeneration (Alzheimer’s, Parkinson’s models)
Immune dysregulation, chronic inflammation
Alcohol/opioid withdrawal (reduces anxiety/craving)

Contraindications

Hypersensitivity to Selank or excipients
Severe depression with suicidal ideation (monotherapy insufficient)
Pregnancy/lactation (limited safety data)
Children <18 years (not approved)

Mechanism of Action (Molecular & Cellular)

A. GABAergic System (Primary Anxiolytic Pathway)

Positive allosteric modulator (PAM) of GABAₐ receptors (non-benzodiazepine site), enhances GABA binding (no direct agonism), regulates 45–52 GABA-related genes, no sedation/tolerance.

B. Serotonergic & Dopaminergic Modulation

Increases 5-HT turnover/sensitivity, modulates dopamine metabolism in prefrontal cortex/hippocampus, improves mood, focus and emotional resilience.

C. Neurotrophic & Neuroprotective Effects

Upregulates BDNF in hippocampus/prefrontal cortex, supports synaptic plasticity/neuronal survival, reduces oxidative stress/neuroinflammation, protects against excitotoxicity/ischemia.

D. Enkephalinase Inhibition

Inhibits aminopeptidase N/CD13, prolongs endogenous enkephalins for natural analgesic/anxiolytic/anti-stress effects.

E. Immunomodulation

Regulates cytokines (↓IL-6/TNF-α, ↑IL-10), modulates T/B cells, macrophages, NK cells, normalizes stress-induced immune dysfunction.